Nested Layouts

I am trying to create a layout similar to the one mentioned in this knowledge base article:

The layout would contain 4 cells, a,b,c,d.  Two columns: a,b and ONE row. Cells c,d are nested within b.
Here is an image: … layout.jpg

is this possible?

Yes, you should use 2U pattern for primary layout and 2E pattern for secondary layout (use cell-based init for secondary layout).